Structural Proteomics pp 145-159

Part of the Methods in Molecular Biology™ book series (MIMB, volume 426)

Protein Structure Modeling with MODELLER

  • Narayanan Eswar
  • David Eramian
  • Ben Webb
  • Min-Yi Shen
  • Andrej Sali

Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. This chapter presents an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of similar protcols has resulted in models of useful accuracy for domains in more than half of all known protein sequences.

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Narayanan Eswar
    • 1
  • David Eramian
    • 1
  • Ben Webb
    • 1
  • Min-Yi Shen
    • 1
  • Andrej Sali
    • 1
  1. 1.Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry and California Institute for Quantitative Biomedical ResearchUniversity of California at San FranciscoSan FranciscoCalifornia

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