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Structural Proteomics pp 145–159Cite as

Protein Structure Modeling with MODELLER

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 426))

 

Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. This chapter presents an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of similar protcols has resulted in models of useful accuracy for domains in more than half of all known protein sequences.

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Author information

Authors and Affiliations

  1. Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry and California Institute for Quantitative Biomedical Research, University of California at San Francisco, San Francisco, California

    Narayanan Eswar, David Eramian, Ben Webb, Min-Yi Shen & Andrej Sali

Authors
  1. Narayanan Eswar
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  2. David Eramian
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  3. Ben Webb
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  4. Min-Yi Shen
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  5. Andrej Sali
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Editor information

Editors and Affiliations

  1. School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland, Australia

    Bostjan Kobe

  2. School of Molecular and Microbial Biosciences, University of Sydney, Sydney, Australia

    Mitchell Guss

  3. School of Molecular and Microbial Sciences and Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia

    Thomas Huber

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Eswar, N., Eramian, D., Webb, B., Shen, MY., Sali, A. (2008). Protein Structure Modeling with MODELLER. In: Kobe, B., Guss, M., Huber, T. (eds) Structural Proteomics. Methods in Molecular Biology™, vol 426. Humana Press. https://doi.org/10.1007/978-1-60327-058-8_8

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  • DOI: https://doi.org/10.1007/978-1-60327-058-8_8

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-809-6

  • Online ISBN: 978-1-60327-058-8

  • eBook Packages: Springer Protocols

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