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In Vivo Predictive Toxicogenomics

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Essential Concepts in Toxicogenomics

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 460))

Summary

Reference databases consisting of large sample numbers and high-dimensional microarray data are now available for the investigation of adverse events in animal model systems such as the rat. This large volume of data, accompanied by appropriate study designs, compound and dose selection procedure, and minimization of technical and biological confounding effects, can yield successful predictive models for a variety of hypotheses. The process of training, validating, and implementing predictive models is cyclical and complex. This chapter highlights individual decisions that need to be made before, during, and after a model or set of models has been trained, with an emphasis on proper statistical methods and suitable interpretation of the results.

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Author information

Authors and Affiliations

  1. Department of Toxicogenomics, Gene Logic Inc., Gaithersburg, Maryland

    Mark W. Porter

Authors
  1. Mark W. Porter
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Editor information

Editors and Affiliations

  1. Gene Logic Inc, Gaithersburg, MD, USA

    Donna L. Mendrick

  2. The Critical Path Institute, Rockville, MD, USA

    William B. Mattes

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Porter, M.W. (2008). In Vivo Predictive Toxicogenomics. In: Mendrick, D.L., Mattes, W.B. (eds) Essential Concepts in Toxicogenomics. Methods in Molecular Biology™, vol 460. Humana Press. https://doi.org/10.1007/978-1-60327-048-9_6

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  • DOI: https://doi.org/10.1007/978-1-60327-048-9_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-638-2

  • Online ISBN: 978-1-60327-048-9

  • eBook Packages: Springer Protocols

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