Preparation of Drug-Loaded Polymeric Nanoparticles and Evaluation of the Antioxidant Activity Against Lipid Peroxidation

  • Adriana R. Pohlmann
  • Scheila Rezende Schaffazick
  • Tânia B. Creczynski-Pasa
  • Sílvia S. Guterres
Part of the Methods in Molecular Biology book series (MIMB, volume 610)


Antioxidants have been found to be effective as prophylatic and therapeutic agents for different diseases such as diabetes, cancer, and neurodegenerative disorders. However, antioxidant substances can present poor solubility in water, inefficient permeability, gastrointestinal degradation, first-pass effect, and/or instability during storage. These drawbacks can be potentially circumvented by encapsulating the susceptible antioxidants. Polymeric nanoparticles (nanocapsules or nanospheres) have been used to improve the drug efficacy and release. Our group has shown that the in vitro antioxidant effect of melatonin against lipid peroxidation in microsomes and liposomes can be improved by encapsulation of the antioxidant drug in polymeric nanoparticles.

Key words

Polymeric nanoparticles nanospheres nanocapsules antioxidant drug melatonin lipid peroxidation microsomes liposomes 



The authors acknowledge the financial support from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS), Fundação de Amparo à Pesquisa do Estado de Santa Catarina (FAPESC), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Rede Nanocosméticos CNPq/MCT-Brazil.


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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Adriana R. Pohlmann
    • 1
  • Scheila Rezende Schaffazick
    • 2
  • Tânia B. Creczynski-Pasa
    • 3
  • Sílvia S. Guterres
    • 4
  1. 1.Instituto de Química da Universidade Federal do Rio Grande do Sul, UFRGSPorto AlegreBrazil
  2. 2.Pós-Graduação em Ciências Farmacêuticas da Universidade Federal do Rio Grande do Sul, UFRGSPorto AlegreBrazil
  3. 3.Departamento de Ciências FarmacêuticasUniversidade Federal de Santa Catarina, UFSCPorto AlegreBrazil
  4. 4.Faculdade de Farmácia da Universidade Federal do Rio Grande do Sul, UFRGSPorto AlegreBrazil

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