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Innate Immunity pp 403–427Cite as

Models of Caenorhabditis elegans Infection by Bacterial and Fungal Pathogens

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 415))

Summary

The nematode Caenorhabditis elegans is a simple model host for studying the relationship between the animal innate immune system and a variety of bacterial and fungal pathogens. Extensive genetic and molecular tools are available in C. elegans, facilitating an in-depth analysis of host defense factors and pathogen virulence factors. Many of these factors are conserved in insects and mammals, indicating the relevance of the nematode model to the vertebrate innate immune response. Here, we describe pathogen assays for a selection of the most commonly studied bacterial and fungal pathogens using the C. elegans model system.

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Author information

Authors and Affiliations

  1. Department of Molecular Biology, Massachusetts General Hospital, Boston, MA

    Jennifer R. Powell & Frederick M. Ausubel

  2. Department of Genetics, Harvard Medical School, Boston, MA

    Jennifer R. Powell & Frederick M. Ausubel

Authors
  1. Jennifer R. Powell
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  2. Frederick M. Ausubel
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Editor information

Editors and Affiliations

  1. Centre d’Immunologie de Marseille-Luminy, INSERM, CNRS Université de la Méditerranée, Marseille, France

    Jonathan Ewbank  & Eric Vivier  & 

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© 2008 Humana Press Inc.

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Powell, J.R., Ausubel, F.M. (2008). Models of Caenorhabditis elegans Infection by Bacterial and Fungal Pathogens. In: Ewbank, J., Vivier, E. (eds) Innate Immunity. Methods in Molecular Biology™, vol 415. Humana Press. https://doi.org/10.1007/978-1-59745-570-1_24

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  • DOI: https://doi.org/10.1007/978-1-59745-570-1_24

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-746-4

  • Online ISBN: 978-1-59745-570-1

  • eBook Packages: Springer Protocols

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