Model of Acute Injury to Study Neuroprotection

  • Michal Schwartz
  • Jonathan Kipnis
Part of the Methods in Molecular Biology book series (MIMB, volume 399)


A major causative factor in the paralysis that often follows an acute injury to the central nervous system (CNS) is the paradoxical inability of the CNS to tolerate its own mechanism of self-repair. The dismal result is often a wider spread of damage (part of the inevitable “secondary” or “delayed” degeneration) rather than contribution toward a cure. Ever since the phenomenon of posttraumatic damage spread in the CNS was first recognized, neuroscientists have attempted to identify the players in this destructive process and have sought ways to neutralize or bypass them with the object of rescuing any neurons that are still viable. This approach is collectively termed neuroprotection. In this chapter, we present a view of experimental paradigms used to study neuroprotection.

Key Words

Neuroprotection CNS degeneration partial injuries protective autoimmunity 


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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Michal Schwartz
    • 1
  • Jonathan Kipnis
    • 1
    • 2
  1. 1.Department of NeurobiologyThe Weizmann Institute of ScienceRehovotIsrael
  2. 2.Department of Pharmacology and Experimental Neuroscience and Department of Ophthalmology and Visual SciencesUniversity of Nebraska Medical CenterOmaha

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