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Type 2 Diabetes pp 1–17Cite as

Selecting the “Right” Mouse Model for Metabolic Syndrome and Type 2 Diabetes Research

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 560))

Summary

This is not a “Methods” chapter in the traditional sense. Rather, it is an essay designed to help address one of the most frequently asked questions by investigators about to embark on a study requiring an animal model of diabetes - what is the “right” model for the reader’s specific research application. Because genetic heterogeneity and the requirement for complex gene-environment interaction characterize the various mouse models of Type 2 diabetes as well as the human disease manifestations, the readers may come to share the author’s conclusion that more than one model is required if the investigator is interested in knowing how broadly effective a given compound with putative therapeutic efficacy might be.

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Authors and Affiliations

  1. The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA

    Edward H. Leiter

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  1. Edward H. Leiter
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Correspondence to Edward H. Leiter .

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    © 2009 Humana Press, a part of Springer Science+Business Media, LLC

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    Leiter, E.H. (2009). Selecting the “Right” Mouse Model for Metabolic Syndrome and Type 2 Diabetes Research. In: Stocker, C. (eds) Type 2 Diabetes. Methods in Molecular Biology, vol 560. Humana Press. https://doi.org/10.1007/978-1-59745-448-3_1

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    • DOI: https://doi.org/10.1007/978-1-59745-448-3_1

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    • Publisher Name: Humana Press

    • Print ISBN: 978-1-934115-15-2

    • Online ISBN: 978-1-59745-448-3

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