Summary
Study design in understanding gene—environment interaction plays a crucial role. Different study designs with their advantages and limitations are described in this chapter. Gene penetrance has been studied in several cancers, including breast and prostate cancer. Compared with high-penetrance genes, such as breast cancer (BRCA)1, BRCA2 in breast cancer, gene—environment interaction plays a major role in cancer development where low-penetrance genes are the major players. Genetic polymorphism is determined in low- and high-penetrance genes to identify cancer-related polymorphisms. The role of genetic and epigenetic factors in cancer development is discussed. Preventive approaches, especially in the epigenetic field, show promise. A discussion about different epidemiological methods with examples is provided.
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References
Doll R, Peto R. (1981) The causes of cancer. J Natl Cancer Inst 66, 1191–1308.
International Agency for Research on Cancer. (1990) Cancer: causes, occurrence and control. IARC, Lyon, France.
Perera FP, Weinstein IB. (2000) Molecular epidemiology: recent advances and future directions. Carcinogenesis 21, 517–24.
Shields PG, Harris CC. (2000) Cancer risk and low penetrance susceptibility genes in gene-environment interactions. J Clin Oncol 18, 2309–2315.
Khoury MJ, Wagener DK. (1993) Population and familial relative risks of disease associated with environmental factors in the presence of gene-environment interaction. Am J Epidemiol 137, 1241–1250.
Goldstein AM, Andrieu N. (1999) Detection of interaction involving identified genes: available study designs. J Natl Cancer Inst Monogr 26, 49–54.
Yang Q, Khoury M. (1997) Evolving methods in genetic epidemiology. III. Gene-environment interaction in epidemio-logic research. Epidemiol Rev 19, 33–43
Talmud PJ. (2007) Gene-environment interaction and its impact on coronary heart disease risk. Nutr Metab Cardiovasc Dis 17, 148–52.
Khoury MJ, Davis RL, Gwinn M, Lindegren ML, Yoon PW. (2005) Do we need genomic research for the prevention of common diseases with environmental causes? Am J Epidemiol 161, 799–805.
Ritchie MD. (2005) Bioinformatics approaches for detecting gene-gene and gene-environment interactions in studies of human disease. Neurosurg Focus 19, E2.
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© 2009 Humana Press, a part of Springer Science+Business Media, LLC
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Shen, J. (2009). Evaluation of Environmental and Personal Susceptibility Characteristics That Modify Genetic Risks. In: Verma, M. (eds) Cancer Epidemiology. Methods in Molecular Biology, vol 471. Humana Press. https://doi.org/10.1007/978-1-59745-416-2_8
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DOI: https://doi.org/10.1007/978-1-59745-416-2_8
Publisher Name: Humana Press
Print ISBN: 978-1-58829-987-1
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