The Use of Animal Models for Rheumatoid Arthritis

  • Rikard Holmdahl
Part of the Methods in Molecular Medicine book series (MIMM, volume 136)

Abstract

Rheumatoid arthritis (RA) is a description of classical symptoms that can be grouped together to be recognized as a common entity. However, the disease is more heterogeneous and is likely composed of many different, distinct diseases (1). This heterogeneity is of two types. First, the disease can be classified into several subtypes, and second, the underlying cause of each disease group may be attributable to different genetic and environmental factors, each contributing to a distinct disease phenotype. This is an important starting point when discussing animal models for RA. Thus, there is not one model for RA. There are, and must be, several different models with different symptoms and different pathogenic mechanisms, controlled by different genes.

Key Words

Animal model RA 

References

  1. 1.
    Holmdahl, R. (2000) Rheumatoid arthritis viewed using a headache paradigm. Arthritis Res. 2, 175–178.CrossRefGoogle Scholar
  2. 2.
    Abdelnour, A., Bremell, T., Holmdahl, R., and Tarkowski, A. (1994) Clonal expansion of T lymphocytes causes arthritis and mortality in mice infected with toxic shock syndrome toxin-1-producing staphylococci. Eur. J. Immunol. 24(5), 1161–1166.PubMedCrossRefGoogle Scholar
  3. 3.
    Schaible, U. E., Kramer, M. D., Wallich, R., Tran, T., and Simon, M. M. (1991) Experimental Borrelia burgdorferi infection in inbred mouse strains: antibody response and association of H-2 genes with resistance and susceptibility to development of arthritis. Eur. J. Immunol. 21(10), 2397–2405.PubMedCrossRefGoogle Scholar
  4. 4.
    Pearson, C. M. (1956) Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc. Soc. Exp. Biol. Med. 91, 95–101.PubMedGoogle Scholar
  5. 5.
    Wooley, P. H., Seibold, J. R., Whalen, J. D., and Chapdelaine, J. M. (1989) Pristane-induced arthritis. The immunologic and genetic features of an experimental murine model of autoimmune disease. Arthritis Rheum. 32, 1022–1030.Google Scholar
  6. 6.
    Vingsbo, C., Jonsson, R., and Holmdahl, R. (1995) Avridine-induced arthritis in rats; a T cell-dependent chronic disease influenced both by MHC genes and by non-MHC genes. Clin. Exp. Immunol. 99(3), 359–363.PubMedCrossRefGoogle Scholar
  7. 7.
    Vingsbo, C., Sahlstrand, P., Brun, J. G., Jonsson, R., Saxne, T., and Holmdahl, R. (1996) Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes. Am. J. Pathol. 149, 1675–1683.PubMedGoogle Scholar
  8. 8.
    Trentham, D. E., Townes, A. S., and Kang, A. H. (1977) Autoimmunity to type II collagen: an experimental model of arthritis. J. Exp. Med. 146, 857–868.PubMedCrossRefGoogle Scholar
  9. 9.
    Glant, T. T., Mikecz, K., Arzoumanian, A., and Poole, A. R. (1987) Proteoglycaninduced arthritis in Balb/c mice. Arthritis Rheum. 30, 201–212.PubMedCrossRefGoogle Scholar
  10. 10.
    Carlsén, S., Hansson, A. S., Olsson, H., Heinegård, D., and Holmdahl, R. (1998) Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats. Clin. Exp. Immunol. 114(3), 477–484.PubMedCrossRefGoogle Scholar
  11. 11.
    Cremer, M. A., Ye, X. J., Terato, K., Owens, S. W., Seyer, J. M., and Kang, A. H. (1994) Type XI collagen induced arthritis in the Lewis rat. Characterization of cellular and humoral immune responses to native types XI, V, and II collagen and constituent alpha-chains. J. Immunol. 153(2), 824–832.PubMedGoogle Scholar
  12. 12.
    Lu, S., Carlsen, S., Hansson, A-S, and Holmdahl, R. (2002) Immunization of Rats with Homologous Type XI Collagen Leads to Chronic and Relapsing Arthritis with Different Genetics and Joint Pathology Than Arthritis Induced with Homologous Type II Collagen. J. Autoimmun. 18(3), 199–211.PubMedCrossRefGoogle Scholar
  13. 13.
    Verheijden, G. F., Rijnders, A. W., Bos, E., et al. (1997) Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis. Arthritis Rheum. 40(6),1115–1125.PubMedCrossRefGoogle Scholar
  14. 14.
    Schubert, D., Maier, B., Morawietz, L., Krenn, V., and Kamradt, T. (2004) Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. J. Immunol. 172(7), 4503–4509.PubMedGoogle Scholar
  15. 15.
    Iwakura, Y., Tosu, M., Yoshida, E., et al. (1991) Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science 253, 1026–1028.PubMedCrossRefGoogle Scholar
  16. 16.
    Keffer, J., Probert, L., Cazlaris, H., et al. (1991) Transgenic mice expressing human tumour necrosis factor: a predicitive genetic model of arthritis. EMBO J. 10, 4025–4031.PubMedGoogle Scholar
  17. 17.
    Kouskoff, V., Korganow, A. S., Duchatelle, V., Degott, C., Benoist, C., and Mathis, D. (1996) Organ-specific disease provoked by systemic autoimmunity. Cell 87(5), 811–822.PubMedCrossRefGoogle Scholar
  18. 18.
    Sakaguchi, N., Takahashi, T., Hata, H., et al. (2003) Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature 426(6965), 454–460.PubMedCrossRefGoogle Scholar
  19. 19.
    Chabas, D., Baranzini, S. E., Mitchell, D., et al. (2001) The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 294(5547), 1731–1735.PubMedCrossRefGoogle Scholar
  20. 20.
    Blom, T., Franzen, A., Heinegard, D., and Holmdahl, R. (2003) Comment on “The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 299(5614), 1845.PubMedCrossRefGoogle Scholar
  21. 21.
    Dong, P., Hood, L., and McIndoe, R. A. (1996) Detection of a large RIII-derived chromosomal segment on chromosome 10 in the H-2 congenic strain B10.RIII(71NS)/Sn. Genomics 31, 266–269.PubMedCrossRefGoogle Scholar
  22. 22.
    Olofsson, P., Johansson, Å., Wedekind, D., Klöting, I., Klinga-Levan, K., and Holmdahl, R. (2004) Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritisregulating gene Ncf1. Genome 83, 765–771.CrossRefGoogle Scholar
  23. 23.
    Williams, R. O., Feldmann, M., and Maini, R. N. (1992) Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc.Natl.Acad.Sci., USA 89(20), 9784–9788.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc., Totowa, NJ 2007

Authors and Affiliations

  • Rikard Holmdahl
    • 1
  1. 1.Medical Inflammation ResearchLund UniversityLundSweden

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