Locomotor Activity in Rodents

  • Gianluca Tosini
Part of the Methods in Molecular Biology™ book series (MIMB, volume 362)


Many of the behavioral parameters exhibited by an organism show daily fluctuations. These may persist under constant environmental conditions, demonstrating that they are governed by an endogenous (circadian) clock. The monitoring of locomotor activity in rodents is probably one of the most common methods to track this endogenous timing system. The analysis of locomotor activity rhythms can provide several parameters that may be used to describe the status of this endogenous clock. In the past few years several companies have developed hardware and software systems that allow the collection and the analysis of activity data using a personal computer.

Key Words

Locomotor activity free-running period phase shift amplitude rodents 


  1. 1.
    Refinetti, R. (ed.) (1999) Circadian Physiology. CRC Press, Boca Raton, FL.Google Scholar
  2. 2.
    Dunlap, J. C., Loros, J. J., and DeCoursey, P. J. (eds.) (2003) Chronobiology. Biolgical Timekeeping. Sinauer, Sunderland, MA.Google Scholar
  3. 3.
    Tosini, G., and Menaker, M. (2000) Biological clock. In: Frontier of Life, Vol. IV, Biology of Behavior (Alleva, E., and Bateson, P., eds.) Academic Press, San Diego, CA, pp. 163–174.Google Scholar
  4. 4.
    Enright, J. T. (1965) The search for rhythmicity in biological time-series. J. Theoret. Biol. 8, 426–468.CrossRefGoogle Scholar
  5. 5.
    Sokolove, P. G., and Bushnell, W. N. (1978) The chi-square periodogram: Its utility for analysis of circadian rhythms. J. Theoret. Biol. 72, 131–160.CrossRefGoogle Scholar
  6. 6.
    Bloomfield, P. (1976) Fourier Analysis of Time Series: An Introduction. Wiley, New York.Google Scholar
  7. 7.
    Gottman, J. M. (1981) Time-Series Analysis: A Comprehensive Introduction for Social Scientists. Cambridge University Press, New York.Google Scholar
  8. 8.
    Pittendrigh, C. S., and Daan, S. A. (1976) A functional analysis of circadian pacemakers in nocturnal rodents. I. Stability and lability of spontaneous frequency. J. Comp. Physiol. 106, 233–252.Google Scholar

Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Gianluca Tosini
    • 1
  1. 1.Neuroscience InstituteMorehouse School of MedicineAtlanta

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