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DNA Sequence Polymorphism Analysis Using DnaSP

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Bioinformatics for DNA Sequence Analysis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 537))

Abstract

The analysis of DNA sequence polymorphisms and SNPs (single nucleotide polymorphisms) can provide insights into the evolutionary forces acting on populations and species. Available population-genetic methods, and particularly those based on the coalescent theory, have become the primary framework to analyze such DNA polymorphism data. Here, I explain some essential analytical methods for interpreting DNA polymorphism data and also describe the basic functionalities of the DnaSP software. DnaSP is a multi-propose program that allows conducting exhaustive DNA polymorphism analysis using a graphical user-friendly interface.

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Acknowledgments

We thank Sergios-Orestis Kolokotronis for his helpful comments and suggestions on the manuscript. This work was funded by grant BFU2007-62927 from the Dirección General de Investigación Científica y Técnica (Spain), and by grant 2005SGR00166 from Comissió Interdepartamental de Recerca i Innovació Tecnològica de Catalunya (Spain).

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Rozas, J. (2009). DNA Sequence Polymorphism Analysis Using DnaSP. In: Posada, D. (eds) Bioinformatics for DNA Sequence Analysis. Methods in Molecular Biology, vol 537. Humana Press. https://doi.org/10.1007/978-1-59745-251-9_17

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  • DOI: https://doi.org/10.1007/978-1-59745-251-9_17

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-910-9

  • Online ISBN: 978-1-59745-251-9

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