Abstract
Drug delivery across the blood–brain barrier (BBB) is a major obstacle for the development of effective treatments of many central nervous system disorders. Sophisticated cell culture models of the BBB have helped us to identify, characterize, and validate a novel targeted drug delivery technology, designated 2B-Trans™, for the receptor-mediated uptake and transport of drugs across the BBB. This paper describes in great detail how such a BBB cell culture model should be prepared and handled, and applied for the use of targeted drug delivery across the BBB.
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Acknowledgments
Part of the work described in this paper was supported by a grant from ZonMw-Dierproeven Begrensd (3170.0057). The authors would like to acknowledge Drs. Heleen Voorwinden, Dr. Corine Visser, and Drs. Arjen Brink for their excellent experimental contributions to the data presented in this paper.
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© 2008 Humana Press, a part of Springer Science + Business Media, LLC
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Gaillard, P.J., de Boer, A.G. (2008). 2B-Trans™ Technology: Targeted Drug Delivery Across the Blood-Brain Barrier. In: Jain, K.K. (eds) Drug Delivery Systems. Methods in Molecular Biology™, vol 437. Humana Press. https://doi.org/10.1007/978-1-59745-210-6_8
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DOI: https://doi.org/10.1007/978-1-59745-210-6_8
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