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Neural Stem Cells pp 383–401Cite as

Routes of Stem Cell Administration in the Adult Rodent

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 438))

Summary

Stem cell transplantation to replace damaged tissue or correct metabolic disease holds the promise of helping a myriad of human afflictions. Although a great deal of attention has focused on pluripotent stem cells derived from embryos, adult stem cells have been described in a variety of tissues, and they likely will prove to be as beneficial as embryonic stem cells in cell replacement therapy and control of inbred errors of metabolism. We describe methods by which stem cells can be introduced into the nervous system, although the techniques are applicable to any portion of the body to be targeted or any cell that may be used for cell therapy. The first and most straight-forward method is introduction of stem cells directly into the brain parenchyma. The second, which in our hands has proven to be superior in some instances, is introduction of the stem cells into the circulatory system.

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Author information

Authors and Affiliations

  1. Center for Aging and Brain Repair Cell Biology, University of South Florida College of Medicine, Tampa, FL

    Alison E. Willing, Paul R. Sanberg & Samuel Saporta

  2. Center of Excellence in Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, Tampa, FL

    Svitlana Garbuzova-Davis

Authors
  1. Alison E. Willing
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  2. Svitlana Garbuzova-Davis
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  3. Paul R. Sanberg
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  4. Samuel Saporta
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Editor information

Editors and Affiliations

  1. Keck School of Medicine, University of Southern California, 2025 Zonal Ave., Los Angeles, CA 90033, USA

    Leslie P. Weiner

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

About this protocol

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Willing, A.E., Garbuzova-Davis, S., Sanberg, P.R., Saporta, S. (2008). Routes of Stem Cell Administration in the Adult Rodent. In: Weiner, L.P. (eds) Neural Stem Cells. Methods in Molecular Biology™, vol 438. Humana Press. https://doi.org/10.1007/978-1-59745-133-8_30

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  • DOI: https://doi.org/10.1007/978-1-59745-133-8_30

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-846-1

  • Online ISBN: 978-1-59745-133-8

  • eBook Packages: Springer Protocols

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