Abstract
The use of induced pluripotent stem cells (iPSCs) as a cell source for producing cytotoxic T lymphocytes (CTLs) is expected to have advantages in the antigen specificity, rejuvenation profile, and reproducible number of CTLs. We have developed the way to differentiate CD8αβ T cells from TCR-transduced iPSCs (TCR-iPSCs). These T cells express monoclonal expression of the transduced TCR. Generating CD8αβ CTLs from TCR-iPSC could contribute to safe and effective allogeneic regenerative T cell immunotherapies.
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Minagawa, A., Kaneko, S. (2019). Differentiating CD8αβ T Cells from TCR-Transduced iPSCs for Cancer Immunotherapy. In: Kaneko, S. (eds) In Vitro Differentiation of T-Cells. Methods in Molecular Biology, vol 2048. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9728-2_9
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DOI: https://doi.org/10.1007/978-1-4939-9728-2_9
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Publisher Name: Humana, New York, NY
Print ISBN: 978-1-4939-9727-5
Online ISBN: 978-1-4939-9728-2
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