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Preoperative and Intraoperative Markers of Cerebral Ischemia

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Stroke Biomarkers

Part of the book series: Neuromethods ((NM,volume 147))

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Abstract

Different modalities of instrumental neuromonitoring techniques of the risk of cerebral ischemia during carotid endarterectomy (CEA) are described. To assess the rate of ischemic complications, and provide possible solutions to decrease risk factors for carotid clamping (temporary interruption of blood flow through carotid artery during its reconstruction), the selective indwelling shunt and the use of correct intraoperative biomarkers of cerebral ischemia are especially critical. The transcranial Doppler ultrasound (TDUS) examination, cerebral oximetry (CO), and electroencephalography (EEG, evoked potentials) techniques with detailed analyses of principles, methodology, and ischemia thresholds are compared with currently available data. These monitoring modalities during awaked carotid endarterectomy in 148 patients with carotid clamping are evaluated, and potential benefits and limitations are considered for recommendations of the optimal multimodal neuromonitoring strategy based on more sensitive and specific instrumental biomarkers of cerebral ischemia.

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Authors and Affiliations

  1. N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia

    V. A. Lukshin, D. Yu Usachev, A. V. Shmigelsky, A. A. Shulgina & A. A. Ogurtsova

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  1. V. A. Lukshin
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  2. D. Yu Usachev
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  3. A. V. Shmigelsky
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  4. A. A. Shulgina
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  5. A. A. Ogurtsova
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Editor information

Editors and Affiliations

  1. Department of Anatomy, University of Otago, Dunedin, New Zealand

    Philip V. Peplow

  2. Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Lab, Los Alamos, NM, USA

    Bridget Martinez

  3. Brain Biomarkers Research Lab, Emory Decatur Hospital, Emory Healthcare, Decatur, GA, USA

    Svetlana A. Dambinova

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Lukshin, V.A., Usachev, D.Y., Shmigelsky, A.V., Shulgina, A.A., Ogurtsova, A.A. (2020). Preoperative and Intraoperative Markers of Cerebral Ischemia. In: Peplow, P.V., Martinez, B., Dambinova, S.A. (eds) Stroke Biomarkers. Neuromethods, vol 147. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9682-7_17

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  • DOI: https://doi.org/10.1007/978-1-4939-9682-7_17

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