Abstract
Variation in exercise capacity is a translationally powerful indicator for overall health and disease. Here we review the basic methods used for development of theoretically based and hypothesis-driven rat models that divide for both exercise capacity and numerous complex disease risks This rat model system was made by selectively breeding genetically heterogeneous rat populations for low and high performance on a speed ramped treadmill running test.
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Acknowledgments
Development of the LCR-HCR rat model system was supported by NIH grant P40 OD012098A from the Office of Research Infrastructure Programs to L.G.K. and S.L.B. Contact L.G.K. (Lauren.Koch2@UToledo.Edu) or S.L.B. (brittons@umich.edu) for information on the LCR and HCR rats: these rat models are maintained as an international collaborative animal resource at The University of Toledo, Toledo, OH.
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Koch, L.G., Britton, S.L. (2019). Rat Models of Exercise for the Study of Complex Disease. In: Hayman, G., Smith, J., Dwinell, M., Shimoyama, M. (eds) Rat Genomics. Methods in Molecular Biology, vol 2018. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9581-3_15
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DOI: https://doi.org/10.1007/978-1-4939-9581-3_15
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