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Chimera Research pp 43–66Cite as

Cancer Stem Cells: Concepts, Challenges, and Opportunities for Cancer Therapy

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 2005))

Abstract

Cancer stem cells (CSCs) are a subpopulation of cancer cells with self-renewal capacity, that fuel tumor growth and contribute to the heterogeneous nature of tumors. First identified in hematological malignancies, CSC populations have to date been proposed in solid tumors in various organs. In vitro and in vivo assays, mouse genetic models, and more recently single-cell sequencing technologies and other ‘-omics’ methodologies have not only facilitated the identification of novel CSC populations but also revealed and clarified novel properties of CSCs. Increasingly, both cell-autonomous and CSC niche factors are recognized as important contributors of CSC properties. The deepened understanding of CSC properties and characteristics would enable and facilitate the rational design of CSC-specific therapeutics that would, ideally, have high selectivity for cancer cells, eliminate tumor bulk, and prevent tumor recurrence. Addressing these issues would form some of the key challenges of the CSC research field in the coming years.

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Authors and Affiliations

  1. Genome Institute of Singapore, Singapore, Singapore

    May Yin Lee & Wai Leong Tam

  2. Salk Institute for Biological Sciences, La Jolla, CA, USA

    Rajshekhar R. Giraddi

  3. Cancer Science Institute of Singapore, Singapore, Singapore

    Wai Leong Tam

  4. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Wai Leong Tam

  5. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore

    Wai Leong Tam

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  1. May Yin Lee
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  2. Rajshekhar R. Giraddi
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  3. Wai Leong Tam
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Correspondence to Wai Leong Tam .

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  1. Department of Bioethics, Case Western Reserve University, School of Medicine, Cleveland, OH, USA

    Insoo Hyun

  2. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

    Alejandro De Los Angeles

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Lee, M.Y., Giraddi, R.R., Tam, W.L. (2019). Cancer Stem Cells: Concepts, Challenges, and Opportunities for Cancer Therapy. In: Hyun, I., De Los Angeles, A. (eds) Chimera Research . Methods in Molecular Biology, vol 2005. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9524-0_4

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