Abstract
The urgent demand for pure biological and pharmaceutical enantiomers has brought together great efforts in developing chiral techniques. High-performance liquid chromatography employing chiral stationary phases (CSPs) has evolved as a powerful tool for both chiral analysis and manufacture of pure enantiomers. Herein, we describe a facile method to prepare a phenylcarbamate cyclodextrin (CD)-based CSPs via azide/alkyne click chemistry. The functionalities of CD rims are altered to mediate the enantioseparation performance in multimode high-performance liquid chromatography.
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Acknowledgments
The work is financially supported by National Natural Science Foundation of China (Grant No. 51573077, 21305066), Natural Science Foundation of Jiangsu Province (Grant No. BK20170834), and the Fundamental Research Funds for the Central Universities (Grant No. 30917011313).
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Zhou, J., Tang, J., Tang, W. (2019). Functional Cyclodextrin-Clicked Chiral Stationary Phases for Versatile Enantioseparations by HPLC. In: Scriba, G.K.E. (eds) Chiral Separations. Methods in Molecular Biology, vol 1985. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9438-0_8
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DOI: https://doi.org/10.1007/978-1-4939-9438-0_8
Publisher Name: Humana, New York, NY
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