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Non-Natural Nucleic Acids pp 147–162Cite as

Aminoglycoside Functionalization as a Tool for Targeting Nucleic Acids

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1973))

Abstract

Aminoglycoside functionalization as a tool for targeting natural and unnatural nucleic acids holds great promise in their development as diagnostic probes and medicinally relevant compounds. Simple synthetic procedures designed to easily and quickly manipulate amino sugar (neomycin, kanamycin) to more powerful and selective ligands are presented in this chapter. We describe representative procedures for (a) aminoglycoside conjugation and (b) preliminary screening for their nucleic acid binding and selectivity.

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Acknowledgments

We thank the National Institutes of Health (R42GM097917, AI114114, AI120303) for financial support.

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Authors and Affiliations

  1. Department of Chemistry, Clemson University, Clemson, SC, USA

    Derrick Watkins & Krishnagopal Maiti

  2. Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC, USA

    Dev P. Arya

Authors
  1. Derrick Watkins
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  2. Krishnagopal Maiti
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  3. Dev P. Arya
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Corresponding author

Correspondence to Dev P. Arya .

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Editors and Affiliations

  1. Department of Chemistry and Biochemistry, Georgia Southern University, Savannah, GA, USA

    Nathaniel Shank

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Watkins, D., Maiti, K., Arya, D.P. (2019). Aminoglycoside Functionalization as a Tool for Targeting Nucleic Acids. In: Shank, N. (eds) Non-Natural Nucleic Acids. Methods in Molecular Biology, vol 1973. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9216-4_9

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  • DOI: https://doi.org/10.1007/978-1-4939-9216-4_9

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9215-7

  • Online ISBN: 978-1-4939-9216-4

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