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CD8+ T Cell Response to Trypanosoma cruzi Antigens during Chronic Chagas Disease

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T. cruzi Infection

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1955))

Abstract

Flow cytometry is a valuable technique in cellular immunology that allows evaluating effective parameters of the immune response associated with CD8+ T cells. During Chagas disease, infection caused by Trypanosoma cruzi parasite, similar to other intracellular infectious agents, antigen-specific CD8+ T cells are essential for controlling the infection. However, CD8+ T cell response is only partially effective in some chronic Chagas disease patients. Thus, characterization and phenotyping of T. cruzi-specific CD8+ T cells are of great importance during chronic Chagas disease.

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Acknowledgments

We thank the patients and healthy volunteers who participated in the study. We thank the following for financial support: COLCIENCIAS (Code 120349326159) and Pontificia Universidad Javeriana (No. 00006233).

Author information

Authors and Affiliations

  1. Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia

    Paola Lasso, Jose Mateus & Adriana Cuéllar

  2. Grupo de Enfermedades Infecciosas, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia

    Paola Lasso, Jose Mateus & Concepción Puerta

  3. Grupo de Ciencias Básicas Médicas, Facultad de Medicina, Universidad de los Andes, Bogotá, Colombia

    John Mario González

Authors
  1. Paola Lasso
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  2. Jose Mateus
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  3. John Mario González
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  4. Adriana Cuéllar
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  5. Concepción Puerta
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Corresponding author

Correspondence to Paola Lasso .

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Editors and Affiliations

  1. INGEBI-CONICET, Buenos Aires, Argentina

    Karina Andrea Gómez

  2. UNSAM-CONICET, IIB-INTECH, San Martin, Buenos Aires, Argentina

    Carlos Andrés Buscaglia

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Lasso, P., Mateus, J., González, J.M., Cuéllar, A., Puerta, C. (2019). CD8+ T Cell Response to Trypanosoma cruzi Antigens during Chronic Chagas Disease. In: Gómez, K., Buscaglia, C. (eds) T. cruzi Infection. Methods in Molecular Biology, vol 1955. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9148-8_26

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  • DOI: https://doi.org/10.1007/978-1-4939-9148-8_26

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-9147-1

  • Online ISBN: 978-1-4939-9148-8

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