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Bioinformatics and Drug Discovery pp 91–118Cite as

Leveraging Big Data to Transform Drug Discovery

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1939))

Abstract

The surge of public disease and drug-related data availability has facilitated the application of computational methodologies to transform drug discovery. In the current chapter, we outline and detail the various resources and tools one can leverage in order to perform such analyses. We further describe in depth the in silico workflows of two recent studies that have identified possible novel indications of existing drugs. Lastly, we delve into the caveats and considerations of this process to enable other researchers to perform rigorous computational drug discovery experiments of their own.

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Acknowledgments

The research is supported by R21 TR001743, U24 DK116214, and K01 ES028047 (to BC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Authors and Affiliations

  1. Bakar Computational Health Sciences Institute, University of California, San Francisco, CA, USA

    Benjamin S. Glicksberg & Bin Chen

  2. Department of Genetics and Genomic Sciences, Institute of Next Generation Healthcare, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Benjamin S. Glicksberg, Li Li, Rong Chen & Joel Dudley

  3. Sema4, A Mount Sinai Venture, Stamford, CT, USA

    Li Li & Rong Chen

  4. Department of Pediatrics and Human Development, Michigan State University, Grand Rapids, MI, USA

    Bin Chen

  5. Department of Pharmacology and Toxicology, Michigan State University, Grand Rapids, MI, USA

    Bin Chen

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  1. Benjamin S. Glicksberg
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  2. Li Li
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  3. Rong Chen
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  4. Joel Dudley
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  5. Bin Chen
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Correspondence to Bin Chen .

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Editors and Affiliations

  1. Department of Pathology, University of New Mexico, Albuquerque, NM, USA

    Richard S. Larson

  2. Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA

    Tudor I. Oprea

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Glicksberg, B.S., Li, L., Chen, R., Dudley, J., Chen, B. (2019). Leveraging Big Data to Transform Drug Discovery. In: Larson, R., Oprea, T. (eds) Bioinformatics and Drug Discovery. Methods in Molecular Biology, vol 1939. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9089-4_6

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  • DOI: https://doi.org/10.1007/978-1-4939-9089-4_6

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