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In Vivo Models of Rheumatoid Arthritis

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Bone Research Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1914))

Abstract

Rheumatoid arthritis (RA) models in mice induced by immunization enable the analyses of molecular mechanism involved in disease development, progression, and resolution of inflammation. Here, we describe three different models mimicking clinic symptoms of human rheumatoid arthritis, which could be transferable to any genetically modified mouse. We will present the protocol for collagen-induced arthritis (CIA), K/BxN serum-induced arthritis (SIA), and the antigen-induced arthritis (AIA) models. To do so, we will detail their way of induction but also how to analyze RA clinical score and pathology characterization. Finally, we will briefly discuss the main characteristics and disadvantages of all three models.

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Authors and Affiliations

  1. Department of Medicine 3, Rheumatology and Immunology, University Hospital Erlangen, Erlangen, Germany

    Bettina Grötsch, Aline Bozec & Georg Schett

Authors
  1. Bettina Grötsch
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  2. Aline Bozec
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  3. Georg Schett
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Corresponding author

Correspondence to Aline Bozec .

Editor information

Editors and Affiliations

  1. Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

    Aymen I. Idris

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Grötsch, B., Bozec, A., Schett, G. (2019). In Vivo Models of Rheumatoid Arthritis. In: Idris, A. (eds) Bone Research Protocols. Methods in Molecular Biology, vol 1914. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8997-3_14

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  • DOI: https://doi.org/10.1007/978-1-4939-8997-3_14

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8996-6

  • Online ISBN: 978-1-4939-8997-3

  • eBook Packages: Springer Protocols

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