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Free Dyadic Social Interaction Test in Mice

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Pre-Clinical Models

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1916))

Abstract

Psychiatric disorders affect approximately one quarter of people worldwide at some point in their lifetime. This chapter provides a step-by-step guide to conduct behavioral tests in adult mice for investigations of social behavior, without the need for specific equipment. This test should allow the identification of key abnormalities in social interactions that can be followed up by targeted, more complex, behavioral analysis aimed at identification of new biomarkers and potential drug targets.

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References

  1. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5), 5th edn. American Psychiatric Publishing, Washington, DC (31 May 2013). ISBN-10: 0890425558

    Book  Google Scholar 

  2. McArthur RA, Borsini F (eds) (2008) Animal and translational models for CNS drug discovery: psychiatric disorders. Academic Press, New York (20 Nov. 2008). ISBN-10: 0123738563

    Google Scholar 

  3. http://www.who.int/mental_health/world-mental-health-day/2017/en/

  4. Kluge W, Alsaif M, Guest PC, Schwarz E, Bahn S (2011) Translating potential biomarker candidates for schizophrenia and depression to animal models of psychiatric disorders. Expert Rev Mol Diagn 11(7):721–733

    Article  CAS  Google Scholar 

  5. Sarnyai Z, Alsaif M, Bahn S, Ernst A, Guest PC, Hradetzky E et al (2011) Behavioral and molecular biomarkers in translational animal models for neuropsychiatric disorders. Int Rev Neurobiol 101:203–328

    Article  CAS  Google Scholar 

  6. File SE (1980) The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs. J Neurosci Methods 2:219–238

    Article  CAS  Google Scholar 

  7. Lapin IP, Mutovkina LG, Ryzov IV, Mirzaev S (1996) Anxiogenic activity of quinolinic acid and kynurenine in the social interaction test in mice. J Psychopharmacol 10(3):246–249

    Article  CAS  Google Scholar 

  8. File SE, Seth P (2003) A review of 25 years of the social interaction test. Eur J Pharmacol 463:35–53

    Article  CAS  Google Scholar 

  9. Navarro JF, Rivera A, Maldonado E, Cavas M, de la Calle A (2004) Anxiogenic-like activity of 3,4-methylenedioxy-methamphetamine (“Ecstasy”) in the social interaction test is accompanied by an increase of c-fos expression in mice amygdala. Prog Neuro-Psychopharmacol Biol Psychiatry 28(2):249–254

    Article  CAS  Google Scholar 

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Correspondence to Zoltán Sarnyai .

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Kraeuter, AK., Guest, P.C., Sarnyai, Z. (2019). Free Dyadic Social Interaction Test in Mice. In: Guest, P. (eds) Pre-Clinical Models. Methods in Molecular Biology, vol 1916. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8994-2_8

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  • DOI: https://doi.org/10.1007/978-1-4939-8994-2_8

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8993-5

  • Online ISBN: 978-1-4939-8994-2

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