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Hydra as Model to Determine the Role of FOXO in Longevity

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FOXO Transcription Factors

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1890))

Abstract

In non-senescent Hydra, continuously high activity of transcription factor FOXO contributes to continuous stem cell proliferation. Here, we describe how genetic manipulation of Hydra polyps using embryo-microinjection allows uncovering the role of FOXO in coordinating both stem cell proliferation and antimicrobial peptide0073 , effector molecules of the innate immune system, and regulators of the microbiome.

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Acknowledgment

This work was supported by the Deutsche Forschungsgemeinschaft (DFG) (CRC1182 “Origin and Function of Metaorganisms,” DFG grant BO 848/17-1, and grants from the DFG Cluster of Excellence program “Inflammation at Interfaces”). The author gratefully appreciates support from the Canadian Institute for Advanced Research (CIFAR).

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Authors and Affiliations

  1. Zoological Institute, Kiel University, Kiel, Germany

    Thomas C. G. Bosch

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  1. Thomas C. G. Bosch
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Correspondence to Thomas C. G. Bosch .

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Editors and Affiliations

  1. Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Madrid, Spain

    Wolfgang Link

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Bosch, T.C.G. (2019). Hydra as Model to Determine the Role of FOXO in Longevity. In: Link, W. (eds) FOXO Transcription Factors. Methods in Molecular Biology, vol 1890. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-8900-3_19

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  • DOI: https://doi.org/10.1007/978-1-4939-8900-3_19

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-8899-0

  • Online ISBN: 978-1-4939-8900-3

  • eBook Packages: Springer Protocols

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