Abstract
The increase in the number of new substances appearing on the drug market has been observed in the 1980s and 1990s of the last century, when many phenethylamine and tryptamine derivatives entered the market. However, the phenomenon of mass marketing of new designer stimulants (being the components of so-called “legal highs”) began to develop since 2006 in Europe, and it was something new. Since then, the number of stimulants introduced on the drug market is growing regularly, rapidly, and intensively. Such a situation creates a need for comprehensive screening methods for detection of these drugs in biological specimens. The fast and simple liquid chromatography-tandem mass spectrometry qualitative screening procedure presented here is designed to detect and identify a wide range of designer stimulants in the blood. The assay has wide applicability for rapid screening of new stimulants in forensic or clinical samples. The procedure can be easily modified for additional novel psychoactive substances.
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References
European Monitoring Centre for Drugs and Drug Addiction (2017) European Drug Report 2017: Trends and Developments, Publications Office of the European Union, Luxembourg. http://www.emcdda.europa.eu/system/files/publications/4541/TDAT17001ENN.pdf. Accessed 11 July 2017
Zuba D, Adamowicz P (2016) Distinction of constitutional isomers of mephedrone by chromatographic and spectrometric methods. Aust J Forensic Sci 49:637. https://doi.org/10.1080/00450618.2016.1167240
Ellefsen KN, Concheiro M, Huestis MA (2016) Synthetic cathinone pharmacokinetics, analytical methods, and toxicological findings from human performance and postmortem cases. Drug Metab Rev 48(2):237–265. https://doi.org/10.1080/03602532.2016.1188937
Namera A, Kawamura M, Nakamoto A, Saito T, Nagao M (2015) Comprehensive review of the detection methods for synthetic cannabinoids and cathinones. Forensic Toxicol 33(2):175–194
Adamowicz P, Tokarczyk B (2016) Simple and rapid screening procedure for 143 new psychoactive substances by liquid chromatography-tandem mass spectrometry. Drug Test Anal 8(7):652–667
Stone P, Glauner T, Kuhlmann F, Schlabach T, Miller K (2009) New dynamic MRM mode improves data quality and triple quad quantification in complex analyses. Technical overview. Agilent technologies. https://www.agilent.com/cs/library/technicaloverviews/Public/5990-3595en_lo%20CMS.pdf.
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Adamowicz, P., Tokarczyk, B. (2019). Screening Analysis for Designer Stimulants by LC-MS/MS. In: Langman, L., Snozek, C. (eds) LC-MS in Drug Analysis. Methods in Molecular Biology, vol 1872. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8823-5_16
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DOI: https://doi.org/10.1007/978-1-4939-8823-5_16
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