Abstract
The diagnosis of vasculitis in rheumatoid arthritis (RV) is associated with considerable mortality; therefore, understanding the basic mechanisms underlying the pathogenesis of vasculitis is very important. Animal models of vasculitis have contributed to elucidating such mechanisms. We here introduce a Candida albicans water-soluble (CAWS) glycoprotein-induced vasculitis model and the methodological approach to evaluate inflammatory vascular change.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Vollertsen RS, Conn DL, Ballard DJ, Ilstrup DM, Kazmar RE, Silverfield JC (1986) Rheumatoid vasculitis: survival and associated risk factors. Medicine (Baltimore) 65:365–375
Voskuyl AE, Zwinderman AH, Westedt ML, Vandenbroucke JP, Breedveld FC, Hazes JM (1996) The mortality of rheumatoid vasculitis compared with rheumatoid arthritis. Arthritis Rheum 39:266–271
Luzina IG, Handwerger BS (2000) Lessons from animal models of vasculitis. Curr Rheumatol Rep 2:369–375
Miyabe C, Miyabe Y, Miura NN, Takahashi K, Terashima Y, Toda E, Honda F, Morio T, Yamagata N, Ohno N, Shudo K, Suzuki J, Isobe M, Matsushima K, Tsuboi R, Miyasaka N, Nanki T (2013) Am80, a retinoic acid receptor agonist, ameliorates murine vasculitis through the suppression of neutrophil migration and activation. Arthritis Rheum 65:503–512
Shepherd MG, Sullivan PA (1976) The production and growth characteristics of yeast and mycelial forms of Candida albicans in continuous culture. J Gen Microbiol 93:361–370
Uchiyama M, Ohno N, Miura NN, Adachi Y, Aizawa MW, Tamura H, Tanaka S, Yadomae T (1999) Chemical and immunochemical characterization of limulus factor G-activating substance of Candida spp. FEMS Immunol Med Microbiol 24:411–420
Nagi-Miura N, Adachi Y, Ohno N (2008) [Coronary arteritis induced by CAWS (Candida albicans water-soluble fraction) in various strains of mice]. Nippon Ishinkin Gakkai Zasshi 49:287–292
Miura NN, Komai M, Adachi Y, Osada N, Kameoka Y, Suzuki K, Ohno N (2009) IL-10 is a negative regulatory factor of CAWS-vasculitis in CBA/J mice as assessed by comparison with Bruton’s tyrosine kinase-deficient CBA/N mice. J Immunol 183:3417–3424
Chisaka T, Mogi M, Nakaoka H, Kan-No H, Tsukuda K, Wang XL, Bai HY, Shan BS, Kukida M, Iwanami J, Higaki T, Ishii E, Horiuchi M (2016) Low-protein diet-induced fetal growth restriction leads to exaggerated proliferative response to vascular injury in postnatal life. Am J Hypertens 29:54–62
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media, LLC, part of Springer Nature
About this protocol
Cite this protocol
Mogi, M., Liu, S. (2018). Animal Models of Vasculitis. In: Liu, S. (eds) Rheumatoid Arthritis. Methods in Molecular Biology, vol 1868. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8802-0_23
Download citation
DOI: https://doi.org/10.1007/978-1-4939-8802-0_23
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-8801-3
Online ISBN: 978-1-4939-8802-0
eBook Packages: Springer Protocols