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Release of Antibodies and Cytokines from B Cells

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Rheumatoid Arthritis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1868))


Autoreactive B cells play a critical role in rheumatoid arthritis. These cells differentiate into long-living memory B cells and autoantibody-producing plasma cells and also present autoantigens to T cells to amplify misdirected immune responses. The therapeutic benefit of B-cell-deleting therapies suggests that B cells are emerging as important factors in the pathogenesis of RA. Aiming at evaluation of the function of B cells, which are usually derived from peripheral blood of RA patients and healthy donors, it is possible to conduct a series of experiments, such as in vitro assessment of antibody production and BCR-mediated cytokine release. These techniques can also be applied for in vivo application.

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Correspondence to Shuang Liu .

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Liu, S. (2018). Release of Antibodies and Cytokines from B Cells. In: Liu, S. (eds) Rheumatoid Arthritis. Methods in Molecular Biology, vol 1868. Humana Press, New York, NY.

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8801-3

  • Online ISBN: 978-1-4939-8802-0

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