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Cancer Epigenetics for Precision Medicine pp 247–254Cite as

Epigenetic and Genetic Regulation of PDCD1 Gene in Cancer Immunology

Part of the Methods in Molecular Biology book series (MIMB,volume 1856)

Abstract

Utilizing biology of PD-1: PD-L1 interaction related pathways for cancer immunotherapy is an emerging concept in cancer research. However, there is limited literature on epigenetic regulation of PD1 gene (PDCD1). Promising data from clinical trials of PD/PDl-1 immunotherapy in melanoma, renal cancers, colorectal and lung cancers has generated a lot of hope for successful treatment of patients. Immunotherapy in cancers has a significant role in strategizing NCI’s Cancer Moonshot Program of US NIH and FDA policies. The cost of the treatment by immunotherapy is extremely high. This preview presents a concise compilation of current knowledge on how the PD-1 gene is regulated in different cancers and infections. We have also discussed about epigenetic regulation of PDCD1 gene, especially the effect of different epigenetic inhibitors of DNA methylation and histone modifications at different steps in PD-1 regulation.

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Abbreviations

CTCF:

CCCTC-Binding Factor

PD-1:

Programed Cell Death-1

TSS:

Transcription start site

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Author information

Authors and Affiliations

  1. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA

    Alok Mishra

  2. National Cancer Institute, National Institutes of Health, Rockville, MD, USA

    Mukesh Verma

Authors
  1. Alok Mishra
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  2. Mukesh Verma
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Editor information

Editors and Affiliations

  1. Kelly Government Solutions, Bethesda, MD, USA

    Ramona G. Dumitrescu

  2. Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Mukesh Verma

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Mishra, A., Verma, M. (2018). Epigenetic and Genetic Regulation of PDCD1 Gene in Cancer Immunology. In: Dumitrescu, R., Verma, M. (eds) Cancer Epigenetics for Precision Medicine . Methods in Molecular Biology, vol 1856. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8751-1_14

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  • DOI: https://doi.org/10.1007/978-1-4939-8751-1_14

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8750-4

  • Online ISBN: 978-1-4939-8751-1

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