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Influenza Virus pp 461–486Cite as

Selection of Antigenically Advanced Variants of Influenza Viruses

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1836))

Abstract

Influenza virus epidemics are caused when seasonal influenza viruses (i.e., those circulating in humans) acquire mutations in the antigenic sites of the viral hemagglutinin (HA) protein that prevent the antibodies present in people from binding to the virus and blocking virus interaction with cellular receptors. To date, vaccination is the best protective option against seasonal influenza viruses. Because influenza viruses frequently acquire mutations in their antigenic sites, vaccine viruses need to be updated regularly. Here, we present an experimental system that allows the simulation of influenza virus evolution in the test tube. By using this system, we can identify antigenic variants that may emerge among natural influenza viruses in the near future. This information would help in the selection and prioritization of variants for vaccine production.

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Author information

Authors and Affiliations

  1. Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA

    Gabriele Neumann, Shufang Fan & Yoshihiro Kawaoka

  2. Division of Virology, Department of Microbiology and Immunology, University of Tokyo, Tokyo, Japan

    Yoshihiro Kawaoka

  3. International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

    Yoshihiro Kawaoka

Authors
  1. Gabriele Neumann
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  2. Shufang Fan
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  3. Yoshihiro Kawaoka
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Corresponding author

Correspondence to Yoshihiro Kawaoka .

Editor information

Editors and Affiliations

  1. School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

    Yohei Yamauchi

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Neumann, G., Fan, S., Kawaoka, Y. (2018). Selection of Antigenically Advanced Variants of Influenza Viruses. In: Yamauchi, Y. (eds) Influenza Virus. Methods in Molecular Biology, vol 1836. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8678-1_22

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  • DOI: https://doi.org/10.1007/978-1-4939-8678-1_22

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8677-4

  • Online ISBN: 978-1-4939-8678-1

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