Analysis of Population-Genetic Properties of Copy Number Variations

  • Lingyang Xu
  • Yang Liu
  • Derek M. Bickhart
  • JunYa Li
  • George E. Liu
Part of the Methods in Molecular Biology book series (MIMB, volume 1833)


While single nucleotide polymorphisms (SNPs) are typically the variant of choice for population genetics, copy number variations (CNVs) which comprise insertions, deletions and duplications of genomic sequences, is also an informative type of genetic variation. CNVs have been shown to be both common in mammals and important for understanding the relationship between genotype and phenotype. Moreover, population-specific CNVs are candidate regions under selection and are potentially responsible for diverse phenotypes.

Key words

Copy number variation Genetic diversity Population genetics Positive selection 



This work was supported in part by Agricultural Science and Technology Innovation Program of China (ASTIP-IAS-TS-16). L.Y.X was supported by the Elite Youth Program in Chinese Academy of Agricultural Sciences.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Lingyang Xu
    • 1
  • Yang Liu
    • 1
  • Derek M. Bickhart
    • 2
  • JunYa Li
    • 1
  • George E. Liu
    • 3
  1. 1.Institute of Animal ScienceBeijingChina
  2. 2.Research Microbiologist/BioinformaticianUSDA ARS DFRCMadisonUSA
  3. 3.Animal Genomics and Improvement LaboratoryUSDA ARSBeltsvilleUSA

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