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Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells and Tumor

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Targeted Drug Delivery

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1831))

Abstract

Due to the drug resistance of cancer stem cells (CSCs), CSC-targeted delivery of multiple drugs in nanoparticle-based drug delivery system holds great potential for the destruction of the CSCs and Tumor. In this chapter, we describe the preparation of multi-layered pH-responsive polymeric nanoparticles (NPs) by multiple emulsifications to encapsulate multiple hydrophilic and hydrophobic theranostic agents for controlled and sequenced release. Hyaluronic acid (HA) is used for not only actively targeting the CSCs to reduce their drug resistance due to dormancy (i.e., slow metabolism), but also replacing the commonly used poly (vinyl alcohol) (PVA) as a stabilizing agent to synthesize the nanoparticles.

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Acknowledgment

This work was supported by an American Cancer Society (ACS) Research Scholar Grant (No. 120936-RSG-11-109-01-CDD) and an NIH grant (R01CA206366) to X.H., and a Pelotonia Postdoctoral Fellowship to H.W.

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Authors and Affiliations

  1. Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA

    Hai Wang & Xiaoming He

Authors
  1. Hai Wang
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  2. Xiaoming He
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Corresponding author

Correspondence to Xiaoming He .

Editor information

Editors and Affiliations

  1. Vivian L. Smith Department of Neurosurgery, University of Texas Health Science, Center at Houston, Houston, Texas, USA

    Rachael W. Sirianni

  2. Department of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia, USA

    Bahareh Behkam

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Wang, H., He, X. (2018). Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells and Tumor. In: Sirianni, R., Behkam, B. (eds) Targeted Drug Delivery. Methods in Molecular Biology, vol 1831. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8661-3_6

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  • DOI: https://doi.org/10.1007/978-1-4939-8661-3_6

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8659-0

  • Online ISBN: 978-1-4939-8661-3

  • eBook Packages: Springer Protocols

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