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DNA Nanotechnology pp 79–100Cite as

Design and Characterization of pH-Triggered DNA Nanoswitches and Nanodevices Based on DNA Triplex Structures

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1811))

Abstract

Triplex DNA is becoming a very useful domain to design pH-triggered DNA nanoswitches and nanodevices. The high versatility and programmability of triplex DNA interactions allows the integration of pH-controllable modules into DNA-based reactions and self-assembly processes. Here, we describe the procedure to characterize DNA-based triplex nanoswitches and more in general pH-triggered structure-switching mechanisms. Procedures to characterize pH-triggered DNA nanodevices will be useful for many applications in the field of biosensing, drug delivery systems and smart nanomaterials.

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Authors and Affiliations

  1. Department of Chemistry, University of Rome Tor Vergata, Rome, Italy

    Andrea Idili & Francesco Ricci

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  1. Andrea Idili
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  2. Francesco Ricci
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Correspondence to Francesco Ricci .

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Editors and Affiliations

  1. Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

    Giampaolo Zuccheri

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Idili, A., Ricci, F. (2018). Design and Characterization of pH-Triggered DNA Nanoswitches and Nanodevices Based on DNA Triplex Structures. In: Zuccheri, G. (eds) DNA Nanotechnology. Methods in Molecular Biology, vol 1811. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8582-1_6

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  • DOI: https://doi.org/10.1007/978-1-4939-8582-1_6

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  • Publisher Name: Humana Press, New York, NY

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