Sensitivity Enhancement in Capillary Electrophoresis Using Magnetic Particles as Solid-Phase Extraction Sorbents for the Determination of Drugs of Abuse in Urine

  • Tatiana Baciu
  • Francesc Borrull
  • Carme AguilarEmail author
  • Marta Calull
Part of the Methods in Molecular Biology book series (MIMB, volume 1810)


Over the last few years, different types of magnetic particles have been investigated and successfully used in sample preparation, of which iron oxides are the most popular, due to their low price and low toxicity. For analytical purposes, these particles have always been modified and functionalized with different materials to improve their stability and introduce new surface properties. Here we describe the preparation of silica-coated iron oxide particles functionalized with C18 and their application as solid-phase extraction sorbents coupled in-line with capillary electrophoresis for determining drugs of abuse in human urine.

Key words

Capillary electrophoresis Magnetic particles Solid-phase extraction Bioanalysis Drugs of abuse 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Tatiana Baciu
    • 1
  • Francesc Borrull
    • 1
  • Carme Aguilar
    • 1
    Email author
  • Marta Calull
    • 1
  1. 1.Department of Analytical Chemistry and Organic ChemistryUniversitat Rovira i VirgiliTarragonaSpain

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