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Estimation of Community Usage of Drugs Utilizing Sewage Epidemiology

  • Bikram SubediEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1810)

Abstract

Drug abuse is considered to be a national epidemic in many countries including the USA, and is associated with impaired social indicators including economic loss and adverse public health. The conventional methods of estimation of drug usage in communities are based on self-reported surveys, overdose or toxicological reports, drug-related crime statistics, and hospital admissions. Conventional methods suffer from several shortcomings including cost and time intensiveness, nonresponse bias, bias in the selection of sample population, and consumer’s unawareness on the actual composition of used drugs. Sewage epidemiology utilizes the mass load of drugs in wastewater influent to estimate the drug usage in a community. Despite several challenges to the determination of the human excretion profile of drugs, the stability of drugs in wastewater, the dynamics of the population, sewage epidemiology provides several opportunities, including a cost-effective, comprehensive, noninvasive, and nearly real-time measure of trends of drug use over time.

Key words

Sewage epidemiology Community usage Drug abuse Illicit drugs Wastewater 

References

  1. 1.
    UNODC (United Nation Office on Drugs and Crime) World drug report 2016. http://www.unodc.org/wdr2016/. Accessed 21 March 2017
  2. 2.
    Subedi B, Kannan K (2014) Mass loading and removal of select illicit drugs in two wastewater treatment plants in New York State and estimation of illicit drug usage in communities through wastewater analysis. Environ Sci Technol 48:6661–6670CrossRefPubMedGoogle Scholar
  3. 3.
    Asimakopoulos AG, Kurunthachalam K (2016) Neuropsychiatric pharmaceuticals and illicit drugs in wastewater treatment plants: a review. Environ Chem 13:541–576CrossRefGoogle Scholar
  4. 4.
    Keshaviah A, Gitlin R, Cattell L, Reeves W, de Vallance J, Thronton C (2016) The potential of wastewater testing for rapid assessment of opioid abuse. https://www.mathematica-mpr.com/. Accessed 21 March 2017
  5. 5.
    Subedi B, Loganathan B (2016) Environmental emission of pharmaceuticals from wastewater treatment plants in the U.S.A. In: Persistent organic chemicals in the environment: status and trends in the Pacific Basin countries II Temporal trends, ACS symposium series, vol II. American Chemical Society, Washington, DC, pp 181–202Google Scholar
  6. 6.
    Gonzalez-Marino I, Gracia-Lor E, Rousis NI, Castrignano E, Thomas KV, Quintana JB, Kasprzyk-Hordern B, Zuccato E, Castiglioni S (2016) Wastewater-based epidemiology to monitor synthetic Cathinones use in different European countries. Environ Sci Technol 50:10089–10096CrossRefPubMedGoogle Scholar
  7. 7.
    Castiglioni S, Thomas KV, Kasprzyk-Hordern B, Vandam L, Griffiths P (2014) Testing wastewater to detect illicit drugs: state of the art, potential and research needs. Sci Total Environ 487:613–620CrossRefPubMedGoogle Scholar
  8. 8.
    Khan U, Nicell JA (2011) Refined sewer epidemiology mass balances and their application to heroin, cocaine, and ecstasy. Environ Int 37:1236–1252CrossRefPubMedGoogle Scholar
  9. 9.
    Baker DR, Kasprzyk-Hordern B (2011) Multi-residue analysis of drugs of abuse in wastewater and surface water by solid-phase extraction and liquid chromatography-positive electrospray ionization tandem mass spectrometry. J Chromatogr A 1218:1620–1631CrossRefPubMedGoogle Scholar
  10. 10.
    Postigo C, Alda ML, Barcelo D (2008) Analysis of drugs of abuse and their human metabolites in water by LC-MS2: a non-intrusive tool for drug abuse estimation at the community level. Trends Anal Chem 27:1053–1069CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ChemistryMurray State UniversityMurrayUSA

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