HLA Typing pp 275-284 | Cite as

HLA Haplotype Frequency Estimation from Real-Life Data with the Hapl-o-Mat Software

  • Jürgen SauterEmail author
  • Christian Schäfer
  • Alexander H. Schmidt
Part of the Methods in Molecular Biology book series (MIMB, volume 1802)


HLA haplotype frequencies are of use in a variety of settings. Such data is typically derived either from family pedigree data by targeted typing or statistical analysis of large population-specific genotype samples. As established tools for the latter approach lacked ability to treat the amount, ambiguity, and inhomogeneity found in genotype data in hematopoietic stem cell donor registries, we developed Hapl-o-Mat to alleviate these specific shortcomings.


HLA Immunogenetics Population genetics Bioinformatics Haplotype Expectation-maximization algorithm Open-source software 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Jürgen Sauter
    • 1
    Email author
  • Christian Schäfer
    • 1
  • Alexander H. Schmidt
    • 1
  1. 1.DKMS gemeinnützige GmbHTübingenGermany

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