Comprehensive HLA Typing from a Current Allele Database Using Next-Generation Sequencing Data
HLA allele information is essential for a variety of medical applications, such as genomic studies of multifactorial diseases, including immune system and inflammation-related disorders, and donor selection in organ transplantation and regenerative medicine. To obtain this information, an accurate HLA typing method that is applicable for any allele registered in HLA allele databases is needed. Here, we describe a method for determining alleles from a current HLA database using next-generation sequencing (NGS) results.
KeywordsHLA typing NGS Software Database Bioinformatics
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