HLA Typing pp 215-223 | Cite as

HLA Typing from Short-Read Sequencing Data with OptiType

  • András SzolekEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1802)


The established standards for HLA genotyping rely on targeted DNA sequencing techniques. However, the increasing abundance of short-read sequencing data has prompted a demand for computational tools capable of HLA typing from general purpose sequencing data as well. OptiType is a software that performs HLA typing from short-read DNA and RNA sequencing data, and this chapter guides the user through its installation and usage.


HLA class I typing RNA-Seq Whole-exome Seq OptiType Mapping In silico Bioinformatics 


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Applied Bioinformatics, Department for Computer ScienceUniversity of TübingenTübingenGermany

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