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Thyroid Hormone Receptors: Several Players for One Hormone and Multiple Functions

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Book cover Thyroid Hormone Nuclear Receptor

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1801))

Abstract

Thyroid hormone receptors (TRs) were cloned based on their homology with the retroviral oncogene v-ERBA. In Vertebrates two genes, THRA and THRB, encode respectively many isotypes and isoforms of receptors TRα and TRβ, resulting from alternative splicing and/or internal transcription start sites. We present here a wide overview of this diversity and of their mechanisms of action as transcription regulators, as well as alternative actions through cytoplasmic signaling.

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Author information

Authors and Affiliations

  1. Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Université de Lyon, Hospices Civils de Lyon, Lyon, France

    Jacques Samarut

  2. Département de la Recherche, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Lyon, France

    Michelina Plateroti

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  1. Jacques Samarut
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  2. Michelina Plateroti
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Correspondence to Jacques Samarut or Michelina Plateroti .

Editor information

Editors and Affiliations

  1. Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France

    Michelina Plateroti

  2. École normale supérieure de Lyon, Lyon, France

    Jacques Samarut

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Samarut, J., Plateroti, M. (2018). Thyroid Hormone Receptors: Several Players for One Hormone and Multiple Functions. In: Plateroti, M., Samarut, J. (eds) Thyroid Hormone Nuclear Receptor. Methods in Molecular Biology, vol 1801. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7902-8_1

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  • DOI: https://doi.org/10.1007/978-1-4939-7902-8_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7901-1

  • Online ISBN: 978-1-4939-7902-8

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