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Dystonia

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Clinical Trials in Neurology

Part of the book series: Neuromethods ((NM,volume 138))

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Abstract

Dystonia is a chronic neurological disorder that hinders the quality of life of affected individuals and causes serious disability. It is often an underdiagnosed or misdiagnosed condition due to the lack of clinical criteria and insufficient amount of research studies on the field. With the main goal of exploring methodological aspects of clinical trials in Dystonia, a review of the literature was conducted through the database engine “Web of Science,” searching for the 100 most cited trials in Dystonia, published between 2005 and 2015. This chapter discusses the findings of this review and provides recommendations for augmenting future research studies in the field.

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References

  1. Tarsy D, Simon DK (2006) Dystonia. N Engl J Med 355(8):818–829. https://doi.org/10.1056/NEJMra055549

    Article  PubMed  CAS  Google Scholar 

  2. Defazio G, Abbruzzese G, Livrea P, Berardelli A (2004) Epidemiology of primary dystonia. Lancet Neurol 3(11):673–678. https://doi.org/10.1016/S1474-4422(04)00907-X

    Article  PubMed  Google Scholar 

  3. Albanese A, Barnes MP, Bhatia KP, Fernandez-Alvarez E, Filippini G, Gasser T, Krauss JK, Newton A, Rektor I, Savoiardo M, Valls-Sole J (2006) A systematic review on the diagnosis and treatment of primary (idiopathic) dystonia and dystonia plus syndromes: report of an EFNS/MDS-ES Task Force. Eur J Neurol 13(5):433–444. https://doi.org/10.1111/j.1468-1331.2006.01537.x

    Article  PubMed  CAS  Google Scholar 

  4. Woods JR, Williams JG, Tavel M (1989) The two-period crossover design in medical research. Ann Intern Med 110(7):560–566

    Article  CAS  PubMed  Google Scholar 

  5. Taylor WJ, Weatherall M (2006) What are open-label extension studies for? J Rheumatol 33(4):642–643

    PubMed  Google Scholar 

  6. Messerer D, Porzsolt F, Hasford J, Neiss A (1987) Advantages and problems of multicenter therapy studies exemplified by a study of the treatment of metastasizing renal cell carcinoma with recombinant interferon-alpha-2c. Onkologie 10(1):43–49

    PubMed  CAS  Google Scholar 

  7. Krauss JK (2002) Deep brain stimulation for dystonia in adults. Overview and developments. Stereotact Funct Neurosurg 78(3-4):168–182. 68963

    Article  PubMed  Google Scholar 

  8. Coubes P, Vayssiere N, El Fertit H, Hemm S, Cif L, Kienlen J, Bonafe A, Frerebeau P (2002) Deep brain stimulation for dystonia. Surgical technique. Stereotact Funct Neurosurg 78(3-4):183–191. 68962

    Article  PubMed  Google Scholar 

  9. Kupsch A, Kuehn A, Klaffke S, Meissner W, Harnack D, Winter C, Haelbig TD, Kivi A, Arnold G, Einhaupl KM, Schneider GH, Trottenberg T (2003) Deep brain stimulation in dystonia. J Neurol 250(Suppl 1):I47–I52. https://doi.org/10.1007/s00415-003-1110-2

    Article  PubMed  Google Scholar 

  10. Ostrem JL, Starr PA (2008) Treatment of dystonia with deep brain stimulation. Neurotherapeutics 5(2):320–330. https://doi.org/10.1016/j.nurt.2008.01.002

    Article  PubMed  PubMed Central  Google Scholar 

  11. Jankovic J, Hunter C, Dolimbek BZ, Dolimbek GS, Adler CH, Brashear A, Comella CL, Gordon M, Riley DE, Sethi K, Singer C, Stacy M, Tarsy D, Atassi MZ (2006) Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia. Neurology 67(12):2233–2235. https://doi.org/10.1212/01.wnl.0000249308.66959.43

    Article  PubMed  CAS  Google Scholar 

  12. Francisco GE (2004) Botulinum toxin: dosing and dilution. Am J Phys Med Rehabil 83(10 Suppl):S30–S37

    Article  PubMed  Google Scholar 

  13. Rossetto O, Seveso M, Caccin P, Schiavo G, Montecucco C (2001) Tetanus and botulinum neurotoxins: turning bad guys into good by research. Toxicon 39(1):27–41

    Article  CAS  PubMed  Google Scholar 

  14. Simpson LL (1981) The origin, structure, and pharmacological activity of botulinum toxin. Pharmacol Rev 33(3):155–188

    PubMed  CAS  Google Scholar 

  15. Pagan FL, Harrison A (2012) A guide to dosing in the treatment of cervical dystonia and blepharospasm with Xeomin(R): a new botulinum neurotoxin A. Parkinsonism Relat Disord 18(5):441–445. https://doi.org/10.1016/j.parkreldis.2012.02.008

    Article  PubMed  Google Scholar 

  16. Brin MF (1997) Botulinum toxin: chemistry, pharmacology, toxicity, and immunology. Muscle Nerve Suppl 6:S146–S168

    Article  CAS  PubMed  Google Scholar 

  17. Comella CL, Jankovic J, Shannon KM, Tsui J, Swenson M, Leurgans S, Fan W, Dystonia Study G (2005) Comparison of botulinum toxin serotypes A and B for the treatment of cervical dystonia. Neurology 65(9):1423–1429. https://doi.org/10.1212/01.wnl.0000183055.81056.5c

    Article  PubMed  CAS  Google Scholar 

  18. Consky E, Basinki A, Belle L, Ranawaya L, Lang A (1990) The Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS): assessment of validity and inter-rater reliability. Neurology 40(suppl 1):445

    Google Scholar 

  19. Gimeno H, Tustin K, Selway R, Lin JP (2012) Beyond the Burke-Fahn-Marsden dystonia rating scale: deep brain stimulation in childhood secondary dystonia. Eur J Paediatr Neurol 16(5):501–508. https://doi.org/10.1016/j.ejpn.2011.12.014

    Article  PubMed  Google Scholar 

  20. Guettard E, Roze E, Abada G, Lemesle C, Vidailhet M, Laurent-Vannier A, Chevignard MP (2009) Management of spasticity and dystonia in children with acquired brain injury with rehabilitation and botulinum toxin A. Dev Neurorehabil 12(3):128–138. https://doi.org/10.1080/17518420902927994

    Article  PubMed  Google Scholar 

  21. Portney LG, Watkins MP (2009) Foundations of clinical research: applications to practice, 3rd edn. Pearson/Prentice Hall, Upper Saddle River, NJ

    Google Scholar 

  22. Stallard N, Whitehead J, Todd S, Whitehead A (2001) Stopping rules for phase II studies. Br J Clin Pharmacol 51(6):523–529

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Volkmann J, Mueller J, Deuschl G, Kuhn AA, Krauss JK, Poewe W, Timmermann L, Falk D, Kupsch A, Kivi A, Schneider GH, Schnitzler A, Sudmeyer M, Voges J, Wolters A, Wittstock M, Muller JU, Hering S, Eisner W, Vesper J, Prokop T, Pinsker M, Schrader C, Kloss M, Kiening K, Boetzel K, Mehrkens J, Skogseid IM, Ramm-Pettersen J, Kemmler G, Bhatia KP, Vitek JL, Benecke R, dystonia DBSsgf (2014) Pallidal neurostimulation in patients with medication-refractory cervical dystonia: a randomised, sham-controlled trial. Lancet Neurol 13(9):875–884. https://doi.org/10.1016/S1474-4422(14)70143-7

    Article  PubMed  Google Scholar 

  24. Chan HY, Chang CJ, Chiang SC, Chen JJ, Chen CH, Sun HJ, Hwu HG, Lai MS (2010) A randomised controlled study of risperidone and olanzapine for schizophrenic patients with neuroleptic-induced acute dystonia or parkinsonism. J Psychopharmacol 24(1):91–98. https://doi.org/10.1177/0269881108096070

    Article  PubMed  CAS  Google Scholar 

  25. Levin J, Singh A, Feddersen B, Mehrkens JH, Botzel K (2014) Onset latency of segmental dystonia after deep brain stimulation cessation: a randomized, double-blind crossover trial. Mov Disord 29(7):944–949. https://doi.org/10.1002/mds.25780

    Article  PubMed  Google Scholar 

  26. Byl NN, Archer ES, McKenzie A (2009) Focal hand dystonia: effectiveness of a home program of fitness and learning-based sensorimotor and memory training. J Hand Ther 22(2):183–197; quiz 198. https://doi.org/10.1016/j.jht.2008.12.003

    Article  PubMed  Google Scholar 

  27. McKenzie AL, Goldman S, Barrango C, Shrime M, Wong T, Byl N (2009) Differences in physical characteristics and response to rehabilitation for patients with hand dystonia: musicians’ cramp compared to writers’ cramp. J Hand Ther 22(2):172–181; quiz 182. https://doi.org/10.1016/j.jht.2008.12.006

    Article  PubMed  Google Scholar 

  28. Rice J, Waugh MC (2009) Pilot study on trihexyphenidyl in the treatment of dystonia in children with cerebral palsy. J Child Neurol 24(2):176–182. https://doi.org/10.1177/0883073808322668

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratory of Neuromodulation, Center of Clinical Research Learning, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA

    Celeste R S De Camargo, Daniel Dresser, Laura Castillo-Saavedra & Felipe Fregni

  2. Spaulding Research Institute, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA, USA

    Felipe Fregni

Authors
  1. Celeste R S De Camargo
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  2. Daniel Dresser
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  3. Laura Castillo-Saavedra
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  4. Felipe Fregni
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Corresponding author

Correspondence to Felipe Fregni .

Editor information

Editors and Affiliations

  1. Laboratory of Neuromodulation, Center of Clinical Research Learning, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Felipe Fregni

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De Camargo, C.R.S., Dresser, D., Castillo-Saavedra, L., Fregni, F. (2018). Dystonia. In: Fregni, F. (eds) Clinical Trials in Neurology. Neuromethods, vol 138. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7880-9_6

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  • DOI: https://doi.org/10.1007/978-1-4939-7880-9_6

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7879-3

  • Online ISBN: 978-1-4939-7880-9

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