Abstract
Parkinson’s disease (PD) is recognized as one of the most common neurologic disorders, with an imperative need for research and new therapeutic interventions. Considering these characteristics, the aim of this book chapter is to analyze the 100 most cited clinical trials in PD, thus outlining methodological aspects, limitations, and challenges involved in this field. A systematic search of the literature between 2010 and 2015 was performed using the electronic database Web of Science. The main findings are reported and discussed as to contribute to the advance of clinical research in this area.
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Notes
- 1.
Access to Web of Science was provided by Countway Library—Harvard Medical School.
- 2.
Some chapters in this book used an extended search for 10 years.
- 3.
Little, R (2014) The Prevention and Treatment of Missing Data in Clinical Trials. N ENGL MED 367;14.
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Acknowledgments
The authors would like to acknowledge Cristina Russo, Aura Hurtado, Felipe Jones, Anthony O’Brien, Beatriz Costa, Isadora Ferreira, and Felipe Fregni for the manuscript review.
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Villarreal, M.F., Huerta-Gutierrez, R., Fregni, F. (2018). Parkinson’s Disease. In: Fregni, F. (eds) Clinical Trials in Neurology. Neuromethods, vol 138. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7880-9_5
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