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Disorders of Consciousness

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Clinical Trials in Neurology

Part of the book series: Neuromethods ((NM,volume 138))

Abstract

Disorders of consciousness (DOC) place numerous challenges to healthcare professionals and clinical investigators, as they involve a variety of pathophysiological mechanisms, which are not yet clearly understood. Research studies have been conducted for promoting a better comprehension on these neurological conditions and making progress on diagnostic and therapeutic approaches. This book chapter presents information collected in a review of the 70 most cited clinical trials in DOC. This review was conducted by using the online database “Web of Science” searching for articles published between 1995 and 2015. Essential methodology and design aspects of these reviewed studies, based on the CONSORT guidelines, are deeply discussed in this chapter with a view to improve the conduction of clinical trials on disorders of consciousness and provide recommendations for advancing the field.

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Authors and Affiliations

  1. Laboratory of Neuromodulation, Center of Clinical Research Learning, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, USA

    Anthony O’Brien, Prakyat Singh, Aurore Thibaut & Felipe Fregni

  2. Spaulding Research Institute, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA, USA

    Felipe Fregni

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  2. Prakyat Singh
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Correspondence to Felipe Fregni .

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  1. Laboratory of Neuromodulation, Center of Clinical Research Learning, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Felipe Fregni

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O’Brien, A., Singh, P., Thibaut, A., Fregni, F. (2018). Disorders of Consciousness. In: Fregni, F. (eds) Clinical Trials in Neurology. Neuromethods, vol 138. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7880-9_3

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