Abstract
Macrophages are present in most of the tissues in the organism. They are basically separated into two categories: the resident macrophages, specific of the tissue and capable of proliferation, and the macrophages deriving from the monocyte differentiation. In the bone marrow, the “resident” macrophages are part of the hematopoietic stem cell niche.
Those macrophages are known to have a role in the support of erythropoiesis (Chow, Nat Med 19:429–436, 2013), the maintenance of stem cell in their niches (Chow, J Exp Med 208:261–271, 2011), and are an independent self-renewing population (Hashimoto, Immunity 38:792–804, 2013).
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References
Chow A, Lucas D, Hidalgo A et al (2011) Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med 208:261–271
Christopher MJ, Rao M, Liu F et al (2011) Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. J Exp Med 208:251–260
Winkler IG, Sims NA, Pettit AR et al (2010) Bone marrow macrophages maintain hematopoietic stem cells (HSC) niches and their depletion mobilizes HSCs. Blood 116:4815–4828
Ehninger A, Trumpp A (2011) The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. J Exp Med 208:421–428
Chow A, Huggins M, Ahmed J et al (2013) CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med 19:429–436
Hashimoto D, Chow A, Noizat C et al (2013) Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38:792–804
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Chalot, M. (2018). Isolation and Phenotyping of Bone Marrow Macrophages. In: Rousselet, G. (eds) Macrophages. Methods in Molecular Biology, vol 1784. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7837-3_8
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DOI: https://doi.org/10.1007/978-1-4939-7837-3_8
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Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-7836-6
Online ISBN: 978-1-4939-7837-3
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