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A Review of Transcriptome Analysis in Pulmonary Vascular Diseases

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Gene Expression Analysis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1783))

Abstract

Transcriptome analysis is a powerful tool in the study of pulmonary vascular disease and pulmonary hypertension. Pulmonary hypertension is a disease process that consists of several unique pathologies sharing a common clinical definition, that of elevated pressure within the pulmonary circulation. As such, it has become increasingly important to identify both similarities and differences among the different classes of pulmonary hypertension. Transcriptome analysis has been an invaluable tool both in the basic science research on animal models as well as clinical research among the various different groups of pulmonary hypertension. This work has identified new potential candidate genes, implicated numerous biochemical and molecular pathways in diseased onset and progression, developed gene signatures to appropriately classify types of pulmonary hypertension and severity of illness, and identified novel gene mutations leading to hereditary forms of the disease.

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Author information

Authors and Affiliations

  1. Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA

    Dustin R. Fraidenburg & Roberto F. Machado

  2. Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    Roberto F. Machado

Authors
  1. Dustin R. Fraidenburg
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  2. Roberto F. Machado
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Correspondence to Roberto F. Machado .

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Editors and Affiliations

  1. Division of Geriatrics and Clinical Gerontology, National Institute on Aging, Bethesda, Maryland, USA

    Nalini Raghavachari

  2. Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, Mississippi, USA

    Natàlia Garcia-Reyero

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Fraidenburg, D.R., Machado, R.F. (2018). A Review of Transcriptome Analysis in Pulmonary Vascular Diseases. In: Raghavachari, N., Garcia-Reyero, N. (eds) Gene Expression Analysis. Methods in Molecular Biology, vol 1783. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7834-2_13

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  • DOI: https://doi.org/10.1007/978-1-4939-7834-2_13

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7833-5

  • Online ISBN: 978-1-4939-7834-2

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