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Motor Assessment in Huntington’s Disease Mice

  • Stephen B. DunnettEmail author
  • Simon P. Brooks
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1780)

Abstract

Motor deficits are a characteristic consequence of striatal damage, whether induced by experimental lesions, or in genetic models of Huntington’s disease involving polyglutamine expansion in the huntingtin protein. With the growing power of genetic models and genetic tools for analysis, mice are increasingly the animal model of choice, and objective quantitative measures of motor performance are in demand for experimental analysis of disease pathophysiology, progression, and treatment. We present methodological protocols for six of the most common tests of motor function—ranging from spontaneous activity, locomotor coordination, balance, and skilled limb use—that are simple, effective, efficient, and widely used for motor assessment in Huntington’s disease research in experimental mice.

Keywords

Motor tests Transgenic mice Rotarod Locomotor activity Raised beam Gait analysis Staircase test Motor coordination Balance Dyskinesia 

Notes

Acknowledgments

We thank Ugo Basile and Campden Instruments for granting permission to reproduce Figs. 2 and 5, respectively. SBD declares a financial interest in receiving royalty payments from Campden Instruments on commercial sales of the staircase test apparatus.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Brain Repair GroupCardiff UniversityCardiffUK
  2. 2.The Brain Repair Group, School of BiosciencesCardiff UniversityCardiffUK

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