A General Method to Prepare Peptide-Based Supramolecular Hydrogels

  • Dan Yuan
  • Junfeng Shi
  • Ning Zhou
  • Bing Xu
Part of the Methods in Molecular Biology book series (MIMB, volume 1777)


As a type of versatile soft materials, supramolecular hydrogels made of peptides have received increasing research attention in past decade and have found useful applications in many areas. Meanwhile, numerous methods have been reported to initiate hydrogelation via noncovalent intermolecular interactions. Generally, most hydrogelation starts from a homogeneous solution and reaches a balance of water hydration and hydrophobic interactions, thereby resulting in hydrogelation. Here, we describe a general method to prepare supramolecular hydrogels of small peptides, and describe two examples to demonstrate hydrogel preparation.

Key words

Peptide Hydrogelation pH Enzyme 



This work was partially supported by grant from NIH (CA142746) and Keck Foundation.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Brandeis UniversityWalthamUSA

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