Hydrogel Printing Based on UV-Induced Projection for Cell-Based Microarray Fabrication
A considerable number of studies have focused on fabrication of hydrogel microstructures due to its wide applications in tissue engineering, drug delivery, and extracellular matrix construction. Here, we introduce a hydrogel printing method based on UV-induced projection via a digital micromirror device (DMD). Arbitrary microstructures could be fabricated within few seconds (<3) by modulating UV projection using DMD as digital dynamic masks instead of a physical mask, which also offers a high degree of flexibility and repeatability. Furthermore, the ability of PEGDA film to hinder cell adhesion makes it possible to control area over which cells attach.
Key wordsMicrofabrication Hydrogel Microwell Cell pattern
This work was partially supported by the National Natural Science Foundation of China (Project Nos. 61302003, 61475183, and 61503258), the NSFC/RGC Joint Research Scheme (Project No. 51461165501), and the CAS FEA International Partnership Program for Creative Research Teams.