ChromothripsisDB: A Curated Database for the Documentation, Visualization, and Mining of Chromothripsis Data
ChromothripsisDB (http://cgma.scu.edu.cn/ChromothripsisDB) is a manually curated database containing a unified description of published chromothripsis cases and relevant genomic aberrations. Available data includes copy number alterations, chromosome structural variations, and gene annotations. The criteria used for detecting chromothripsis in each study are also provided. At present, the molecular mechanisms involved in chromothripsis phenomenon are not fully understood. Thus, further studies with large number of identified chromothripsis samples are needed. The current release of ChromothripsisDB contains more than 400 patient samples, representing over 100 research articles. It represents an extraordinary resource for mining the existing knowledge of chromothripsis.
KeywordsDatabase Copy number alteration Chromosome structural variation Genomic aberration Cancer genome Data mining
This work was funded by the National Natural Science Foundation of China [grant numbers 31571314 and U1603120].