Testing Cell-Based Immunotherapy for Colorectal Cancer
Cell-based immunotherapy for cancer is emerging as an attractive alternative to conventional small-molecule or antibody-based treatment. Due to the characteristics of cell-based therapy, validation of test materials before in vivo administration is required. Here we describe general validation steps for preclinical evaluation of cell-based immunotherapy. We also describe a xenograft model of human colorectal cancer. This model can be used for applied to preclinical evaluation of various cell-based therapy regimens for colorectal cancer treatment.
Key wordsImmunotherapy Immune cells Colorectal cancer Cell line Human tumor xenograft model
This work was supported by grants funded by the KRIBB Research Initiative Program and the Korean Government (NRF-2008-0062275).