In Vivo-Like Growth Patterns of Multiple Types of Tumors in Gelfoam® Histoculture
Diverse human tumors obtained directly from surgery or biopsy can grow at high frequency in 3-dimensional Gelfoam® histoculture for long periods of time and still maintain many of their in vivo properties. The in vivo properties maintained in vitro include 3-dimensional growth; maintenance of tissue organization and structure, such as changes associated with oncogenic transformation; retention of differentiated function; tumorigenicity; and growth of multiple types of cells from a single tumor.
Key wordsGelfoam® histoculture Tumors 3-Dimensional Tissue architecture function
- 12.Hoffman RM (2010) Histocultures and theiruse. In: Encyclopedia of life sciences. Wiley,Chichester. https://doi.org/10.1002/9780470015902.a0002573.pub2
- 13.Hoffman RM (2013) Tissue culture. In: Brenner’s encyclopedia of genetics, 2nd edn, vol. 7. Elsevier, pp. 73–76.Google Scholar