Mouse Genome Informatics (MGI) Is the International Resource for Information on the Laboratory Mouse

  • MeiYee Law
  • David R. ShawEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 1757)


Mouse Genome Informatics (MGI, web resources provide free access to meticulously curated information about the laboratory mouse. MGI’s primary goal is to help researchers investigate the genetic foundations of human diseases by translating information from mouse phenotypes and disease models studies to human systems. MGI provides comprehensive phenotypes for over 50,000 mutant alleles in mice and provides experimental model descriptions for over 1500 human diseases. Curated data from scientific publications are integrated with those from high-throughput phenotyping and gene expression centers. Data are standardized using defined, hierarchical vocabularies such as the Mammalian Phenotype (MP) Ontology, Mouse Developmental Anatomy and the Gene Ontologies (GO). This chapter introduces you to Gene and Allele Detail pages and provides step-by-step instructions for simple searches and those that take advantage of the breadth of MGI data integration.

Key words

MGI MGD GXD MouseMine Mouse Alleles Phenotypes Genotypes Disease models Gene expression Functional annotations Strains IMSR MTB 



These MGI projects are supported by NIH/NHGRI grants: HG000330 and HG002273, NIH/NICHD grant: HD062499, and NIH/NCI CA089713.


  1. 1.
    Blake JA, Eppig JT, Kadin JA, Richardson JE, Smith CL, Bult CJ, Mouse Genome Database Group (2017) Mouse Genome Database (MGD)-2017: community knowledge resource for the laboratory mouse. Nucleic Acids Res 45:D723–D729CrossRefPubMedGoogle Scholar
  2. 2.
    Finger JH, Smith CM, Hayamizu TF, McCright IJ et al (2017) The mouse Gene Expression Database (GXD): 2017 update. Nucleic Acids Res 45:D730–D736CrossRefPubMedGoogle Scholar
  3. 3.
    Bult CJ, Krupke DM, Begley DA et al (2015) Mouse Tumor Biology (MTB): a database of mouse models for human cancer. Nucleic Acids Res 43:D818–D824CrossRefPubMedGoogle Scholar
  4. 4.
    Eppig JT, Motenko H, Richardson JE et al (2015) The International Mouse Strain Resource (IMSR): cataloging worldwide mouse and ES cell line resources. Mamm Genome 26:448–455CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Smith C, Eppig JT (2015) Expanding the mammalian phenotype ontology to support automated exchange of high throughput mouse phenotyping data generated by large-scale mouse knockout screens. J Biomed Semantics 6:11CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Drabkin HJ, Christie KR, Dolan ME et al (2015) Application of comparative biology in GO functional annotation: the mouse model. Mamm Genome 26:574–583CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Köhler S, Vasilevsky NA, Engelstad M et al (2017) The Human Phenotype Ontology in 2017. Nucleic Acids Res 45:D865–D876CrossRefPubMedGoogle Scholar
  8. 8.
    Hayamizu TF, Baldock RA, Ringwald M (2015) Mouse anatomy ontologies: enhancements and tools for exploring and integrating biomedical data. Mamm Genome 26:422–430CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Kibbe WA, Arze C, Felix V et al (2014) Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data. Nucleic Acids Res 43:D1071–D1078CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Motenko H, Neuhauser SB, O’Keefe M et al (2015) MouseMine: a new data warehouse for MGI. Mamm Genome 26:325–330CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Theiler K (1989) The house mouse: atlas of embryonic development. Springer, New YorkCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Mouse Genome InformaticsThe Jackson LaboratoryBar HarborUSA

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