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Mouse Genome Informatics (MGI) Is the International Resource for Information on the Laboratory Mouse

  • MeiYee Law
  • David R. ShawEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 1757)

Abstract

Mouse Genome Informatics (MGI, http://www.informatics.jax.org/) web resources provide free access to meticulously curated information about the laboratory mouse. MGI’s primary goal is to help researchers investigate the genetic foundations of human diseases by translating information from mouse phenotypes and disease models studies to human systems. MGI provides comprehensive phenotypes for over 50,000 mutant alleles in mice and provides experimental model descriptions for over 1500 human diseases. Curated data from scientific publications are integrated with those from high-throughput phenotyping and gene expression centers. Data are standardized using defined, hierarchical vocabularies such as the Mammalian Phenotype (MP) Ontology, Mouse Developmental Anatomy and the Gene Ontologies (GO). This chapter introduces you to Gene and Allele Detail pages and provides step-by-step instructions for simple searches and those that take advantage of the breadth of MGI data integration.

Key words

MGI MGD GXD MouseMine Mouse Alleles Phenotypes Genotypes Disease models Gene expression Functional annotations Strains IMSR MTB 

Notes

Acknowledgments

These MGI projects are supported by NIH/NHGRI grants: HG000330 and HG002273, NIH/NICHD grant: HD062499, and NIH/NCI CA089713.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Mouse Genome InformaticsThe Jackson LaboratoryBar HarborUSA

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