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Esophageal Adenocarcinoma pp 119–134Cite as

Predictive Marker: HER2 in Esophageal Adenocarcinoma

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1756))

Abstract

HER2 positivity is based on the fundamental principle of amplification of the human epidermal growth factor receptor 2 (HER2) gene resulting in overexpression of the protein products . Arising from that a “HER2-positive cancer” is one that shows HER2 gene amplification and resultant protein expression as demonstrated by in situ hybridization and immunohistochemistry, respectively. Testing of the HER2 status is crucial to ensure selection of the correct patient who may benefit from target therapy for esophageal adenocarcinoma. Accurate testing is dependent on several pre-analytical and analytical factors including sample selection, laboratory techniques, and accurate interpretation of HER2 test results.

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Author information

Authors and Affiliations

  1. University Surgical Unit, The National Hospital of Sri Lanka, Colombo, Sri Lanka

    Duminda Subasinghe

  2. Immunohistochemistry, Anatomical Pathology, PathWest, QE2 Medical Centre, Perth, WA, Australia

    Nathan Acott

  3. PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, WA, Australia

    M. Priyanthi Kumarasinghe

  4. School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, WA, Australia

    M. Priyanthi Kumarasinghe

Authors
  1. Duminda Subasinghe
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  2. Nathan Acott
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  3. M. Priyanthi Kumarasinghe
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Corresponding author

Correspondence to M. Priyanthi Kumarasinghe .

Editor information

Editors and Affiliations

  1. Cancer Molecular Pathology of School of Medicine, Griffith University, Gold Coast, Australia

    Alfred K. Lam

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Subasinghe, D., Acott, N., Kumarasinghe, M.P. (2018). Predictive Marker: HER2 in Esophageal Adenocarcinoma. In: Lam, A. (eds) Esophageal Adenocarcinoma. Methods in Molecular Biology, vol 1756. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7734-5_11

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  • DOI: https://doi.org/10.1007/978-1-4939-7734-5_11

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7733-8

  • Online ISBN: 978-1-4939-7734-5

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